Peripheral blood mucosal-associated invariant T cells in tuberculosis patients and healthy mycobacterium tuberculosis-exposed controls

S Suliman; A Gela; SC Mendelsohn; SK Iwany; KL Tamara; S Mabwe; N Bilek; F Darboe; M Fisher; AJ Corbett; L Kjer-Nielsen; SBG Eckle; CC Huang; Z Zhang; DM Lewinsohn; J McCluskey; J Rossjohn; M Hatherill; SR León; RI Calderon; L Lecca; M Murray; TJ Scriba; I van Rhijn; D Branch Moody

Journal article

Peripheral blood mucosal-associated invariant T cells in tuberculosis patients and healthy mycobacterium tuberculosis-exposed controls

S Suliman, A Gela, SC Mendelsohn, SK Iwany, KL Tamara, S Mabwe, N Bilek, F Darboe, M Fisher, AJ Corbett, L Kjer-Nielsen, SBG Eckle, CC Huang, Z Zhang, DM Lewinsohn, J McCluskey, J Rossjohn, M Hatherill, SR León, RI Calderon Show all

Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2020

DOI: 10.1093/infdis/jiaa173

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Abstract

Background. In human blood, mucosal-associated invariant T (MAIT) cells are abundant T cells that recognize antigens presented on non-polymorphic major histocompatibility complex-related 1 (MR1) molecules. The MAIT cells are activated by mycobacteria, and prior human studies indicate that blood frequencies of MAIT cells, defined by cell surface markers, decline during tuberculosis (TB) disease, consistent with redistribution to the lungs. Methods. We tested whether frequencies of blood MAIT cells were altered in patients with TB disease relative to healthy Mycobacterium tuberculosis-exposed controls from Peru and South Africa. We quantified their frequencies using MR1 tetramers loaded with 5..

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University of Melbourne Researchers

Alexandra Corbett Author

Sidonia Eckle Author

McCluskey James Author

Jamie Rossjohn Author

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This study was funded by the National Institutes of Health (NIH) TB Research Unit Network (Grant U19 AI111224-01), the National Institute of Allergy and Infectious Diseases (R01 AI049313), the Strategic Health Innovation Partnerships Unit of the South African Medical Research Council with funds received from the South African Department of Science and Technology and a research grant from Aeras. A. J. C. is supported by a Future Fellowship (FT160100083) from the Australian Research Council. S. B. G. E. is supported by a DECRA Fellowship (DE170100407) from the Australian Research Council. S. C. M. received training in research that was supported by the Fogarty International Centre of the NIH under Award Number D43 TW010559.